The Wrestle Factory was founded in January, 2002 by Mike Quackenbush and Tom "Reckless Youth" Carter in Allentown, PA. After the professional debut of their first class of students that May, and the birth of the CHIKARA organization, Carter departed the company to pursue business interests outside of pro-wrestling. In March of 2005, The Wrestle Factory moved from Allentown to Philadelphia, absorbing the existing CZW school at the "New Alhambra,” better known as the ECW Arena. The staff of the Wrestle Factory was periodically augmented by other instructors during this time, most notably Jorge "Skayde" Rivera of Dragon Gate/Toryumon, Chris Hero, and legendary luchador El Pantera.

In March of 2007, The Wrestle Factory separated from the CZW training facility, but the Wrestle Factory remained stationed at The Arena in Philadelphia for years to come. That October, Claudio Castagnoli was promoted from his role as guest trainer to head trainer, alongside Mike Quackenbush, to aid in the training of the ninth term of students. Shortly thereafter, Sara Del Rey became a Wrestle Factory co-trainer as well.

Claudio Castagnoli (known during his WWE tenure as “Cesaro”) signed with World Wrestling Entertainment in August of 2011, and departed The Wrestle Factory. The following year, Sara Del Rey (now "Sara Amato") also signed with the WWE, to accept a role as coach at their Performance Center in Orlando, FL.

After 2 years in Huntingdon Valley, The Wrestle Factory returned to the City of Brotherly Love once more. Beginning in 2015, while installed on Wingate Street, The Wrestle Factory expanded its training schedule to include more options, more classes and more in-ring hours than ever before. During these years, several of the country's finest wrestlers were promoted to the position of "co-trainer," including Sonny Defarge, Fire Ant, Travis Huckabee and Drew Gulak. In the summer of 2020, our faculty was restructured, the position of "head trainer" was eliminated, and all coaches now share in the title of "coach."

At the end of 2022, The Wrestle Factory made its return to the Lehigh Valley, taking residence in a new space just outside of Allentown, in idyllic Coplay, Pennsylvania.